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Four components of the COP9 signalosome complex (CSN)a deNEDDylase that regulates the ubiquitination activity of cullin-RING E3 ligases and modulates various targets in inflammation 46 were identified as exosome-mediated, itaconated secreted proteins (Fig

J Neurochem 83:984991 Stridh MH, Tranberg M, Weber SG, Blomstrand F, Sandberg M (2008) Stimulated efflux of amino acids and glutathione from cultured hippocampal slices by omission of extracellular calcium: likely involvement of connexin hemichannels

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The NAD + abundance as well as the NAD + /NADH ratio, therefore, decline significantly even with the induction of the de novo synthesis from the KP in response to the lipopolysaccharide (LPS) challenge