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Biological Functions The cytosolic enzyme nicotinamide N-methyltransferase (NNMT) has been newly discovered to modulate the levels of nicotinamide precursors required for NAD+ biosynthesis and thus plays a crucial role in regulating the NAD+ salvage pathway and cellular metabolism

Ethics declarations Ethical Approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards

In vitro research refers to experimental procedures conducted outside of living organisms within controlled laboratory environments for analytical and investigative study

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