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Abbreviations ASCA anti- Saccharomyces cerevisiae antibody FGID functional gastrointestinal disorders GF germ-free IEB intestinal epithelial barrier IBD inflammatory bowel disease IBS irritable bowel syndrome IBS-C constipation-predominant irritable bowel syndrome IBS-D diarrhea-predominant irritable bowel syndrome IBS-M irritable bowel syndrome with mixed bowel habit LPS lipopolysaccharides SCFA short-chain fatty acids

Stage-specific interventions should emerge with acute blockade of ferroptotic lipid peroxidation followed by chronic enhancement of mitochondrial biogenesis, all while respecting circadian metabolic rhythms

During drug discovery, the drug-likeness and rule of five proposed by Lipinski (2004) predict that poor absorption is more likely to happen if the drug does not exceed 5 hydrogen bonds (2 in FA) and 10 H-bond acceptors (3 in FA)