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102 In vitro treatment with 1-h H 2 O 2 demonstrated that the catalytic activity of POLG was reduced to 50% of the original level with significantly lower DNA binding efficiency

As is known, LPO is catalyzed by intracellular iron or lipoxygenases and cytochrome P450 oxidoreductase, leading to its deposition in the biomembrane to increase membrane permeability and hence initiate the process of cell death