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Mishra and Kowluru, 2016)

Standard TRT alone suppresses natural testosterone production via the hypothalamic-pituitary-gonadal axis, reducing luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which leads to decreased sperm production and potential infertility

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Together, these biophysical studies indicate that Syn WT monomers engage in selective and specific interactions, exhibiting higher affinity for functionally relevant partner proteins

The restoration of sperm motility parameters by niacin provides mechanistic support for its observed improvements in fertilization and pregnancy outcomes and underscores its potential as a fertility-protective agent in thermally stressed males