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Two commenters stated that workforce distribution has created variable staffing challenges across the country and believes that a backlog of referrals may exist in some states that typically results in therapy being scheduled months in advancesometimes having to schedule new patients over 90 days after they received the referral

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In further embodiments, the invention encompasses a method of inhibiting NNMT in vitro or in vivo by contacting a cell expressing NNMT with one or more cations chosen from Tables 1, 2, 3a, and 3b