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Description

For the FOXO4-DRI treatment group, 50 M FOXO4-DRI (MCE, HY-P4157) was added to the glucose-free DMEM (Gibco, Catalog #11966-025) medium, followed by 3 h of oxygen-glucose deprivation (OGD) treatment

Figure 1b details how cell viability distribution changes with concentration

These bonds are strong, but they aren't invincible

In the classical ferroptosis regulatory pathway, GSH is depleted by erastin or other system Xc- inhibitors, which reduces cysteine synthesis and leads to GSH synthesis disorder [2, 72, 73]