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In this assay, the 30 min incubation duration was chosen to be optimal because of the inherently cytotoxic nature of CuCl 2 and Cu(OAc) 2 towards HaCaT keratinocytes, as they were observed to cause substantial cell death at a duration longer than 30 mins

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The total program is typically three to four months of active protocol time

It completed Phase 2 trials in obesity [3] and type 2 diabetes [4] and moved into a Phase 3 program (TRIUMPH)