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SAH-hydrolytic assays were performed with equal amounts of wild type SahH (SahH-WT) and SahH-H363A, where the mutant was found to be completely inactive (Fig

NO is generated by three different isoforms of the enzyme nitric oxide synthase (NOS), namely, inducible iNOS, endothelial eNOS, and neuronal nNOS

However, LA increased hepatic cholesterol and reduced LDL receptor protein conversion regulatory factors compared with the model group despite reduced mRNA expression of hepatic cholesterol synthesis enzyme (HMG-CoAr) and blood levels of cholesterol and LDL

ACh regulates Ca 2+ levels and transcription factor expression through muscarinic receptors, while acetylcholinesterase (AChE) promotes the breakdown of ACh

[0385] The anti-ALPP/ALPPL2 antibodies described herein can be coupled directly to the radio-opaque moiety (e.g., at an available cysteine) or they can be attached to a "package" (e.g., a chelate, a liposome, a polymer microbead, a nanoparticle, etc.) carrying, containing, or comprising the radio-opaque material, e.g., as described below