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Because mitochondria naturally produce free radicals during energy production, antioxidant systems like glutathione play an important role in helping maintain balance

J Nippon Med Sch

Further experiments confirmed that acrylamide decreased mitochondrial membrane potential (MMP) and increased ROS production and Nrf2 levels, leading to GSH deactivation and GPX4 degradation and inevitably inducing oxidative stress and ferroptosis (47,104)