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doi: 10.1007/978-1-61779-867-2_20 28 FlohLGunzlerWA

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The main contribution of this paper was that they highlight the metabolic effects of partial mTOR pathway inhibition by rapamycin and rapalogs to economize resources when cells are exposed to nutrient deficiency and hypoxic conditions, which could promote survival of tumor cells hence, highlighting the use of dual mTORC1/mTORC2 inhibition because such inhibitors are able to target dividing cells more efficiently (220)