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In the ischemic environment, microglia tend to polarize toward the M1 phenotype, releasing pro-inflammatory factors such as IL-1 and TNF-, while also activating oxidative stress and matrix metalloproteinases, leading to degradation of tight junction proteins and endothelial dysfunction (138)

Dietary plants for the prevention and management of kidney stones: Preclinical and clinical evidence and molecular mechanisms

J.Rosales-CorralS

Van Leuven, L

Commonly reported issues include: Mild irritation or redness at the injection site Headaches Fatigue Nausea These effects tend to resolve quickly and do not usually require medical intervention