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doi: 10.1016/j.ddstr.2006.03.004

Increased DNMT3B levels accelerate the DNA methylation of the Pink1 (PTEN induced kinase 1) promoter, inhibiting PINK1 expression and promoting ferroptosis and brain damage[129]

J Biol Chem 1982

Particle size as a key factor, wherein smaller nanoparticles tend to have increased toxicity profiles because of their increased cellular penetration ability and enhanced surface reactivity that allows them to interact more with plant cell constituents and metabolic processes (263, 264)