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This resistance is mediated by different causes and mechanisms, (that are resumed in Table 1 and excellently summarized in different review articles [78].One of the most obvious and intriguing mechanisms of resistance involves alteration in CD38 expression, a crucial factor in both primary and acquired resistance to anti-CD38 therapies

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Well explore the molecular basis of this selectivity, compare it to full-length growth hormone and other interventions, examine the clinical evidence for its targeted effects, and discuss practical implications for individuals seeking fat loss without metabolic or endocrine disruption