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Ogasawara et al., 2013) and return to baseline levels ~30 min after RE (Kraemer et al., 2017), which may play an important role for exercise-induced hypertrophy (Kido et al., 2016), neurogenesis (Trejo et al., 2001), and improved muscle strength with RET (Bjersing et al., 2011) and satellite cell proliferation (Velloso, 2008) in muscle and in the central nervous system (CNS) (Mainardi et al., 2015)

Thus, following guidelines is very important

The dose that reaches fibroblasts is still low compared to what systemic delivery achieves

This is documented in the Phase III data and is one of the reasons we screen baseline glucose metabolism at intake

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