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Researchers gave 32 men with ED a combination of intranasal PT-141 (either 7.5 or 10 mg) plus oral sildenafil (50 or 100 mg), then used a RigiScan device to objectively measure erectile rigidity over 6 hours.Impressively, adding PT-141 to sildenafil increased the duration of erectile activity by over five-fold compared to sildenafil alone

This study investigated the hepatoprotective effect of CUR against liver injury in a high-fat diet/streptozotocin (HFD/STZ)-induced T2DM mouse model and elucidated the underlying mechanisms

The company submitted a New Drug Application to the United States Food and Drug Administration in December 2025, based on the REDEFINE 1 and REDEFINE 2 results, with a decision anticipated late in 2026

In human HCT116, A549, HepG2, and MCF-7 cell lines, the prodrugs toxicity was significantly lower than SN38

The data also indicate that pyridoxine supplementation only reduces the hyperhomocysteinemia detected after oral methionine administration in vitamin B 6 -deficient patients or in heterozygotes for CBS deficiency