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10.1097/MCO.0b013e328333d157 329

Sustained denervation leads to progressive atrophy, myocyte death, and fibrosis with irreversible muscle impairment

Under normal conditions, NRF2 is degraded by its negative regulator KEAP1 via the ubiquitin-proteasome pathway [10]

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A compromised gut barrier is both a cause and a consequence of dysbiosis, and intervening at the level of mucosal integrity, which is precisely what BPC-157 does in animal models, represents a mechanistically coherent approach to gut-mediated systemic aging