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Cell 172, 409e21

343 A dietary restriction regimen retarded the progression of neuropathological, behavioral, and metabolic abnormalities in an HD model, resulting in an extension of life span by increasing brain-derived neurotrophic factor and chaperone heat-shock protein-70 (HSP70) levels in the striatum and cortex, the mechanisms of which still need further explanation

At the end of the treatment the cells were collected by trypsinization and counted using Countess Automated Cell Counter from Life Technologies (Gaithersburg, MD, USA) according to the manufacturers instruction

and a brother, Henry Burton

J Neurochem 66 : 16171624 Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH