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Indian J Endocrinol Metab

Firstly, CD206 was employed as the M2 macrophage marker to confirm macrophage polarization status using immunofluorescence staining performed under inflammatory stimuli (LPS and IFN-)

Both increase collagen production but through different mechanisms and with different tolerability profiles

However, timing and sequencing are important to avoid irritation and optimize results

Researched applications In the published preclinical and clinical literature the effects of Cagrilintide are documented in the following areas: Obesity (stand-alone) , Phase 2 data (Lau 2021, 10.8 % at 4.5 mg) Obesity + Semaglutide (CagriSema) , Phase 3 REDEFINE 1 (25.3 %) T2DM + obesity , Phase 3 REDEFINE 2 Cardiovascular prevention , Phase 3 REDEFINE 3 (n ~ 7000) MASLD/MASH , exploratory in Phase 2 Type 2 diabetes (monotherapy) , preclinical data Prediabetes , exploratory plans Science & studies 4.1 Key publications Lau D.C.W., Erichsen L., Francisco A.M., et al