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Comprehensive clinical research demonstrates that elevated Hcy levels associated with endothelial dysfunction represent the predisposing factor for the ethiopathogenesis of atherosclerotic processes and hypercoagulability states, which strongly correlate with cardiovascular mortality, coronary artery disease, and stroke

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330 On the other hand, IL-22 signaling also induces the secretion of chemokines involved in the recruitment of neutrophils, monocytes, and macrophages

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Thus, supplementation with -tocopherol may enhance the activity and concentrations of endogenous antioxidants in the liver