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This broad term ignores the fact that the biology of individual types of ROS is highly diverse, and their chemical reactivity and second-order rate vary significantly ( to form the highly oxidative peroxynitrite (ONOO - ) ( 2 O 2 , , and OH- play important roles in the redox regulation of biological activities ( is decomposed to H 2 O 2 by the action of superoxide dismutase (SOD), which can be further reduced to H 2 O or OH-

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NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )