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In addition, the fourth line of defense may be activated by the reaction and generation of free radicals, which in turn induces the production and transport of corresponding antioxidant enzymes to the effective site and causes the formation of catalase and superoxide dismutase [32, 35]

By activating glucagon signaling in the liver, Retatrutide increases resting metabolic rate and mobilizes hepatic lipid stores, contributing to both weight loss and improvements in metabolic dysfunction-associated steatotic liver disease (MASLD) (Sanyal et al., 2024