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doi: 10.1002/ptr.7225 189 WangWLiMWangLChenLGohBC

Despite its importance, little is known about how to effectively manage fibromyalgia-related sleep problems

Small molecules targeting JAK/STAT and PDE4 pathways such as tofacitinib and apremilast present oral alternatives, though often with reduced efficacy compared to biologics and notable side effects like gastrointestinal intolerance or lipid changes [99]