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Clark WM, Williams BJ, Selzer KA, Zweifler RM, Sabounjian LA, Gammans RE

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FIGURE 5 Within the co-enriched arginine and proline metabolism pathway, the upregulation of PYCR3 (encoding pyrroline-5-carboxylate reductase) and downregulation of PH4A1 (proline hydroxylase) collectively contributed to elevated intracellular proline levels (Figure 5B)

In high L-arginine-dependent tumors, such as breast cancer (Abdelmagid et al., 2013), and HCC (Kishikawa et al., 2015), increased expression of the transporter CAT-1 ( SLC7A1 ) has been observed, and CAT-1 ( SLC7A1 ) knockdown decreases the viability of cancer cells and induces apoptosis