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A recent study has indicated the increased expression of genes involved in matrix degradation, hypoxia-responsive, and inflammatory signaling in damaged cartilages comparing with healthy counterparts through whole genome microarray analysis, suggesting potential involvement of HIF-1 during the progression of OA pathophysiology (Yudoh et al., 2005

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The resulting average crystallite size was found to be approximately 23 nm, suggesting nanoscale grain formation with reasonably uniform distribution

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