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Patients may experience mild to severe infusion reactions such as chills, itching, high temperature, hives, difficulty breathing, and chest pain

Although the specific mechanism of hemolysis induced by bacterial and viral infection is largely unclear, it has been postulated that phagocytic leukocytes may play a role, through generation of hydrogen peroxide during the phagocytic process (61)

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Immunochemical analysis of sulfonamide drug allergy: identification of sulfamethoxazole-substituted human serum proteins