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Additionally, designing the next-generation CARs, such as multi-targeted CARs, programmable CARs, or armored CARs, and constructs with increased secretion of cytokines, expression of co-stimulatory molecule ligands, and suppressed tumor-derived T cell inhibitory signals, along with utilizing genome editing systems like CRISPR/Cas9 can be recommended to be paid more attention

RS is funded by a National Institute for Health Research (NIHR) CDF-2016-09-038 Career Development Fellowship

Dihydroartemisinin (DHA) Artemisinin (ART) is the active component extracted from Artemisia annua , and DHA, its main active derivative, has been shown to exert desired cytotoxic effects on various human malignancies (153156)

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Trenkner, Taurine as a modulator of excitatory and inhibitory neurotransmission, Neurochem Res 29(1) (2004) 189-197