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Coenzyme Q redox signalling and longevity

Animal models confirm TMAOs pathogenic role: reducing plasma TMAO slows CKD progression (138), while TMAO accelerates diabetic nephropathy by activating NLRP3 inflammasome, promoting IL-1/IL-18 release, and worsening renal dysfunction/fibrosis (139)

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Future research should employ pragmatic and innovative strategies: first, leveraging real-world data through nested case-control studies linking dietary supplement usage with cancer registries to generate preliminary epidemiological insights into the association between long-term L-carnitine use and HCC incidence in MASLD populations

Additionally, it is linked to poor diet or certain long-term health conditions where the body struggles to maintain adequate carnitine levels on its own