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Xanthophylls can be obtained from a multitude of natural sources, or produced as described, for example, in U.S

It plays a multi-target, integrated regulatory role through modulation of signaling pathways such as NF-B, MAPK, and Nrf2

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Despite their potential, key challenges for intranasal lipid-based nanoparticles delivery include rapid mucociliary clearance, the selective penetration of the nasal mucosal barrier, and the precise targeting of specific brain regions

Immune cells responsible for inflammation express the vitamin D receptor, and vitamin D successfully suppresses chronic inflammation in multiple settings, while vitamin D deficiency is associated with a pro-inflammatory state (Mohd 2022