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These results suggest that co-treatment with 3-BP and cetuximab induces ferroptosis, autophagy, and apoptosis but not necroptosis in cetuximab-resistant human CRC cell lines

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Of note, FLCN is mutated in Birt-Hogg-Dub syndrome patients, where RagC/D activity and downstream regulation of TFEB/TFE3 seem to be particularly affected, highlighting FLCN-Rag-mTORC1-TFEB as an important signaling axis in human disease (Napolitano et al., 2020)