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Permissive role of vascular endothelium in fibrosis: focus on the kidney

They identified the ER stress sensor IRE1 as a key regulator

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Meanwhile, the expression of Nrf2 is suppressed by Glutathione S-transferase zeta 1 (GSTZ1), which ia an enzyme in the catabolism of phenylalanine significantly downregulated in sorafenib-resistant hepatoma cells (Wang Q