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3,4 Correlation between overall percentage improvement in LS and TH BMD was evaluated for each treatment using Pearsons correlation coefficient (r)

The TRAP staining showed there was more abundance and activity of osteoclasts in Atg7 f/f ;Vav-iCre mice

However, in PD pathogenesis, oligomerisation of S downregulates Sirt3 (Park et al., 2020), resulting in decreased phosphorylation of AMPK and increased phosphorylation of Drp1, impairing mitochondrial respiration, and leading to apoptosis

Abu-Lafi et al

[82, 83] Also, literature has shown that even at the dose of 6 mg/kg, JMV2959 does not affect locomotion per se [12, 22, 84,85,86]