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Change in stool frequency: A significant change in the frequency of bowel movements, manifesting as either diarrhea or constipation

doi: 10.1016/j.cell.2013.12.010 116 JiangXStockwellBRConradM

suggest that the improvement in insulin parameters could be due to the inhibition of COX-2 expression, P-selectin, or inflammatory cytokines such as TNF- and IL-1