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Moreover, suppression of the mTOR-p70S6K axis is able to induce possessing of unique metabolic features, distinguished by high glucose uptake, incremental lactate production, and low mitochondrial respiration, in TNBC cells ( Estrogen Receptor More than two-thirds of the breast cancer cases present as ER-positive, and cancers with ER-positive without HER2-positive is termed as luminal breast cancer (204)

Zhang Y, Griendling KK, Dikalova A, Owens GK, Taylor WR

As of this writing there is no completed large controlled human safety trial

Deng Y, Zou J, Hong Y, et al