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Choi SI, Shin YC, Lee JS, Yoon YC, Kim JM, Sung MK

Notably, pharmacological inhibition of the PI3K-AKT-mTOR pathway reverses Sunitinib- and Sorafenib-resistant phenotypes driven by aberrant AKT activation, underscoring that this pathway represents a potential therapeutic node to overcome drug resistance (267, 272)

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