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10.1111/j.1749-6632.2012.06574.x 11 Brigelius-FlohR.MaiorinoM

Naturally occurring antioxidant found in every cell

In contrast, the N-terminal part of HECT E3s is structurally variable and primarily mediates substrate recognition

The redox status has been suggested to regulate stem cell self-renewal and differentiation, and accumulating evidence indicates that stem cells undergo self-renewal in the environment with low ROS levels, while ROS levels increase in differentiated stem cells [117, 118]