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Dysfunction of the carnitine transporter OCTN2 is the cause of Primary Carnitine Deficiency (PCD), which is characterized by systemic loss of carnitine with severe clinical manifestations, including fertility issues in both males and females

This is especially important when valproate use is considered for a condition not usually associated with permanent injury or death such as prophylaxis of migraine headaches [seeContraindications (4)]

For example, elevated TMAO is linked to heart disease, but seafood is the biggest source of dietary TMAO and virtually every blue zone (regions where people routinely live to be 100) eats a good amount of fish

Avoid ingesting excessive amounts that could trigger symptoms of nausea or diarrhea