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Cells were incubated in TUNEL reaction mixture (Roche, Germany) at 37 C for one h, washed three times with PBS and incubated in blocking solution for 30 min at room temperature

Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress

Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human caco-2 cells via inhibiting nrf2/ho-1 pathway

In individuals with obesity without T2DM, SURMOUNT- 1 evaluated the safety and effectiveness of tirzepatide 5, 10, and 15 mg once weekly in comparison to a placebo when paired with a 500 kcal/day deficit diet and recommendations for 150 min of weekly exercise [118]