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Lysosomes and autophagy are the main regulators of inflammation through nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) signalling and inflammasome activation [140]

Seven of the 22 peptides associated with the frail vs control diagnostic contrast and cognitive decline were cytoskeleton-related, including proteoforms of MAP2, VIM, TUBB, DBN1, TUBA8, PALM and NEFM (Fig

V.: A map of global peatland extent created using machine learning (Peat-ML), Geoscientific Model Development, 15, 47094738, 2022

Potential biomarkers of phenotypic conversion, target engagement and therapeutic efficacy have now emerged

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