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The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are nuclear receptors that regulate genes involved in bilirubin and bile acid detoxification

In this study, we developed an in vitro model of DR by exposing the human retinal pigment epithelial cell line (ARPE-19) to high glucose (HG) injury to test the hypothesis that the antioxidant effect of the Epitalon tetrapeptide improves the delayed healing process associated with hyperglycemia in DR