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This autoimmune response negatively affects neurological functioning and triggers an often rapid, acute onset of Obsessive Compulsive Disorder (OCD), anxiety, restricted food intake, tics and other symptoms, which can develop either very quickly following the illness or have a delay of many months after infection

On the other hand, the oncometabolite 2-hydroxyglutarate (2-HG) competes for the binding site of -KG, acting as a competitive inhibitor of PHD/FIH [82]

doi: 10.1096/fj.201801417R 15

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16 Non-steroidal anti-inflammatories like ibuprofen worsen leaky gut