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Yeo TW, Weinberg JB, Lampah DA, Kenangalem E, Bush P, Chen Y, Price RN, Young S, Zhang HY, Millington D, Granger DL, Anstey NM

Referring to the study by Li et al

Other chemicals engineered for optimal brain penetration rely on exploiting existing mechanisms of barrier entry, including carrier-mediated transport, receptor-mediated transcytosis, adsorptive-mediated transcytosis, and cell mediated transport

Also, CB indirectly assists immune tolerance by upregulating retinol metabolism, reducing pro-inflammatory microbiota (77), and regulating intestinal permeability via miR-200c (80)

2 , 8 It's less effective than metformin head-to-head, but you may find the side-effect profile more favourable