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20 Kameda, M., Teruya, T., Yanagida, M., & Kondoh, H

Safety evaluation of -lipoic acid supplementation: A systematic review and meta-analysis of randomized placebo-controlled clinical studies

However, recent studies have revealed the opposite result

2,4-D Herbicide-induced hepatotoxicity: unveiling disrupted liver functions and associated biomarkers

Both of these direct oxidation processes affect crucial active site cysteine residues and result in a loss of enzymatic activity (Halloran et al., 2013)