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Network pharmacology approaches have revealed multiple active ingredients and signaling pathways in TCM that influence ferroptosis

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These canonical pathways have facilitated the analysis of large transcriptomic datasets, for example, exploring the effects of bariatric surgery on the activation of iron absorption pathways (Evers et al., 2022) or modeling macrophage iron sequestration during host defense against Aspergillus ( Approaches for other nutrient metals While the biophysical and biochemical characteristics of other nutrient metal cofactors differ from those of iron cofactors, the transient nature of the interactions between metallochaperones and client proteins is also characteristic of other metal distribution systems, making the methods described here suitable for the analysis of other metal trafficking systems

Methionine oxidation activates a transcription factor in response to oxidative stress