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Together, these results show that by competing with endogenous FOXO4 for p53 binding, FOXO4-DRI disrupts senescence-associated FOXO4/PML/DNA-SCARS and causes nuclear exclusion of active p53

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Fifthly, all regenerative strategies based on injectable treatments may cause side effects

A molecule that touches several sequential phases, rather than a single step, is consistent with the coordinating signal framing, but it also makes the biology harder to reduce to one clean mechanism and harder to predict when the whole-body copper economy, rather than a walled-off chamber, sets the terms of exposure