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A randomized, double-blind, placebo-controlled trial in 60 healthy older adults (mean age, 68.5 years) investigated whether acute (80 mg) or chronic (80 mg/day for 4 weeks) oral intake of curcumin could improve their ability to cope with the mental stress and change in mood usually associated with undergoing a battery of cognitive tests (97)

Finally, we highlight the challenges that face the therapeutic targeting of the MAT2A/PRMT5 axis, the need for additional predictive biomarkers other than MTAP status, and how these biomarkers could predict rational combination therapies

Caffeine shows significant chronic psychoactive metabolite accumulation with daily use [34], while paraxanthine and 1-MX have mostly-inactive metabolites that are rapidly excreted [35]

[DOI] [PMC free article] [PubMed] [Google Scholar] Szultka M, Buszewska-Forajta M, Kaliszan R, Buszewski B

Aberrant T-cell and B-cell responses lead to the overproduction of autoantibodies and aggravate tissue damage