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In contrast, 25-OHC, produced via cholesterol hydroxylation by cholesterol 25-hydroxylase (CH25H) enzyme in response to interferons and inflammatory cues (Figure 1), links innate immune activation to cholesterol metabolism, exerting potent immunomodulatory and antiviral effects that may become cytotoxic under chronic neuroinflammatory conditions (Dietschy and Turley, 2004

Endocrinology (2008) 149:42433

Sirtuin 7 inhibitor attenuates colonic mucosal immune activation in mice-potential therapeutic target in inflammatory bowel disease

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