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Communication must be documented, and a copy of the information should be handed out to the parents

In this regard, silibinin has been found to be a potentially effective substance in the modulation of mitochondrial dysfunction and the consequence formation of reactive oxygen/nitrogen species that are included in the initiation and progression of chronic liver disease, age-related neurodegenerative disorders, and other chronic diseases [220, 221]

Among the mechanisms impaired by environmental stress are the cytokine-receptor interaction pathway, toll-like receptor signaling pathways, and the production of excessive reactive oxygen species (ROS) in response to multiple impaired immune pathways (Hofmann et al ., 2020)

They cause damage to vessels through by increasing the number of thrombins, causing NOX activation and elevated production of ROS, which leads to DNA and lipid oxidation, concurring to atherosclerosis [57], which has also been confirmed in Jagadeesha et al.s [44] research