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48 Stressors, such as dehydration, fever and infection can lead to a functional decline and neurodegenerative regression in individuals with MD

Because of the structural diversity of natural fatty acids, many seemingly homologous enzymes are known for each step of the -oxidation cycle, including auxiliary enzymes for isomerase and reductase reactions together with acyl-CoA thioesterases, which remove any dead-end products

Thirty-two participants completed Phase I, of whom 29 (90.6%) were classified as high-TMAO producers ( 5 mol/L and 50% increase from baseline to 24-h follow-up)

These data functionally validate our KO cell models

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