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Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice

These medications are generally prescribed for adults with a body mass index (BMI) of 30 kg/m or greater, or 27 kg/m or greater with at least one weight-related comorbidity such as type 2 diabetes or hypertension

METHODS: Animals were randomly allocated to sequentially receive atropine (0.12 mg/kg by rapid injection), pralidoxime (25 mg/kg by injection during 2 minutes), and hydroxocobalamin (75 mg/kg during 10 minutes) by the intravenous or intraosseous route, or atropine and pralidoxime by the intramuscular route

Cell 141 (2), 290303